Scientists at the Salk Institute for Biological Studies have identified patterns of epigenomic diversity that not only allow plants to adapt to various environments, but could also benefit crop production and the study of human diseases.

Published March 6 in Nature, the findings show that in addition to genetic diversity found in plants throughout the world, their epigenomic makeup is as varied as the environments in which they are found. Epigenomics is the study of the pattern of chemical markers that serve as a regulatory layer on top of the DNA sequence. Depending on where they grow, the plants’ epigenomic differences may allow them to rapidly adapt to their environments. (more…) (475)

Saying that the sense of taste is complicated is an understatement, that it is little understood, even more so. Exactly how cells transmit taste information to the brain for three out of the five primary taste types was pretty much a mystery, until now.

A team of investigators from nine institutions discovered how ATP – the body’s main fuel source– is released as the neurotransmitter from sweet, bitter, and umami, or savory, taste bud cells. The CALHM1 channel protein, which spans a taste bud cell’s outer membrane to allow ions and molecules in and out, releases ATP to make a neural taste connection. The other two taste types, sour and salt, use different mechanisms to send taste information to the brain. (more…) (132)

Omega-3 fatty acids found in oily fish may have diverse health-promoting effects, potentially protecting the immune, nervous, and cardiovascular systems.

But how the health effects of one such fatty acid — docosahexaenoic acid (DHA) — works remains unclear, in part because its molecular signaling pathways are only now being understood. (more…) (700)

Jena (Germany) Fish is healthy: easy to digest and with a high level of precious proteins, fish is considered an important part of a healthy diet. And with the so-called omega-3 fatty acids fish contains real ‘fountains of youth’. These fatty acids – like docosahexaeonic acid (DHA) occur mostly in fatty fish like herring, salmon and mackerel. They are thought to lower the blood pressure, to strengthen the immune system and to have positive effects on the development on the nervous system and the cardiovascular system. (more…) (842)

African forest elephants are being poached out of existence. A study just published in the online journal PLOS ONE shows that across their range in central Africa, a staggering 62 percent of all forest elephants have been killed for their ivory over the past decade.

“The analysis confirms what conservationists have feared: the rapid trend towards extinction – potentially within the next decade – of the forest elephant,” says Dr. Samantha Strindberg of the Wildlife Conservation Society (WCS), one of the lead authors of the study. (more…) (133)

The uplift of the Isthmus of Panama 2.6 million years ago formed a land-bridge that has long thought to be the crucial step in the interchange of animals between the Americas, including armadillos and giant sloths moving up into North America and relatives of modern horses, rabbits, foxes, pigs, cats, dogs, and elephants down into South America. (more…) (920)

Building on earlier pioneering work by researchers at the University of California, San Diego, an international consortium of university researchers has produced the most comprehensive virtual reconstruction of human metabolism to date. Scientists could use the model, known as Recon 2, to identify causes of and new treatments for diseases like cancer, diabetes and even psychiatric and neurodegenerative disorders. Each person’s metabolism, which represents the conversion of food sources into energy and the assembly of molecules, is determined by genetics, environment and nutrition. (more…) (138)

A multi-institution group of researchers has found new candidate disease proteins for neurodegenerative disorders. James Shorter, Ph.D., assistant professor of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania, Paul Taylor, M.D., PhD, St. Jude Children’s Research Hospital, and colleagues describe in an advanced online publication of Nature that mutations in prion-like segments of two RNA-binding proteins are associated with a rare inherited degeneration disorder affecting muscle, brain, motor neurons and bone (called multisystem proteinopathy) and one case of the familial form of amyotrophic lateral sclerosis (ALS). (more…) (1256)

Researchers at Pompeu Fabra University (Spain) have created a high resolution atlas of the heart with 3D images taken from 138 people. The study demonstrates that an average image of an organ along with its variations can be obtained for the purposes of comparing individual cases and differentiating healthy forms from pathologies.

“This atlas is a statistical description of how the heart and its components – such as the ventricles and the atrium – look,” as explained to SINC by Corné Hoogendoorn, researcher at the CISTIB centre of the Pompeu Fabra University. (more…) (155)