Hoxful Monsters
Who we’re……..what’s our place……..
Its really heartening to read an article which has neatly designed genetic experiments because its not very often you come across such great genetic work.It surprised me a bit initially not see any biochemical evidence but I personally like this way, may be being a geneticist at heart.Latest issue of development contains an article from the group of Ernesto Sanchez herrero ( an exceptional geneticist) dealing with autoregulation of Hox gene Ultrabithorax (Ubx). Infact autoregulation of Ubx was known since early 90’s but not much was known about mechanism involved and inconsistent, intriguing behaviour due to over expression of Ubx.
Regulation and Autoregulation :
Hox genes encode for transcripton factors containing evolutionary conserved DNA binding domain called “homeodoamin”.These Hox genes are integral part of early embryonic development in Drosophila.The expression domains of Hox genes are set in the embryo by the activity of gap genes and with certain input from pair rule and segment polarity genes the expression is further refined.Hox genes are also known to their own expression, Hox gene deformed does it in a positive way in epidermis and CNS ,whereas Ubx Negatively. (more…)
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Yale molecular and evolutionary biologists in collaboration with Department of Energy scientists produced the full genome sequence of Trichoplax
In order to perform comparative study of Homeodomain containing genes within and in between species ,requires a evolutionary based classification, HomeoDB does that to perfection.
Scientists at Penn State have developed a new computational method that they say will help them to understand how life began on Earth.The team’s method has the potential to trace the evolutionary
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Homologous proteins from primitive species can functionally substitute for thier modern counterpart
A post-doctoral position is available in the laboratory of Marie-Anne Felix, Institut Jacques Monod, CNRS- University Paris 7, Paris, France, starting in the spring of 2009. Possible projects include quantitative studies of the inter cellular signalling network involved in C. elegans vulva development and evolutionary studies of vulva development in the Caenorhabditis genus. For interested candidates, please send a letter of motivation, a Curriculum Vitae and a list of three referees.
Marie-Anne Felix e-mail:felix@ijm.jussieu.fr (more…)
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Casey Dunn is looking for a postdoc in his lab at Brown University.This would be great fun, mixing genomics and microscopy to do some very cool science. Just to remind you ( in case you forget) Cassey dunn is same person who hit headlines with phylogenomics paper in April issue of Nature,which placed Ctenophores at the base of the tree of life. So all finishing graduates, its an interesting opportunity around.
Currently seeking a postdoctoral researcher interested in the evolutionary developmental biology of cnidarians. The primary goal of the project is to advance our understanding of the development of the asexual colonies of the hydroid Hydractinia symbiolongicarpus and the siphonophore Nanomia bijuga. Colonies of both these species consist of functionally specialized polyps and medusae that are produced asexually but remain attached throughout their lives. (more…)
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To keep pace with the newest developments across the globe, any scientist will tell you, is the key to their work. Unfortunately, many scientific institutions have limited information to ongoing research in leading laboratories and little access to the work of top scientists. Now, lectures by some of the world’s leading scientists will be at your fingertips.
iBioSeminars, a free online “library of seminars (akin to iTunes) from the world leaders in biological research” was launched in June, and Bangalore’s National Centre for Biological Sciences (NCBS) will act as a host site. iBioSeminars is the brainchild of Ron Vale, Professor at the University of California, San Francisco (UCSF), and is sponsored by the American Society for Cell Biology, with the support of the Howard Hughes Medical Institute, UCSF Global Health Sciences, and the Carnegie Corporation of New York. (more…)
Sphere: Related ContentThis anemone literally packs up and leaves in under a second.
Quite amazing isn’t it ?
Sphere: Related ContentThe symposium is being organized as a satellite meeting to the international Human Genome Symposium being held in India this year (Sept 2008). The focus of the satellite symposium is to highlight genomic approaches in model organisms and the relevance of these genomic approaches in furthering understanding of complex diseases and drug discovery. The range of model organisms covered includes invertebrates (Drosophila and C. elegans), and vertebrates (Zebrafish and mouse) with a few related talks on human disease.
October 1-2, 2008
Deadline for registrations : 1 September 2008
Conducted @ NCBS ,Bangalore ,India.
Webpage : http://www.ncbs.res.in/
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