Hox genes encode homeodomain (HD) containing transcription factors widely used for diversifying animal body plans in development and evolution. Hox genes were first discovered in Drosophila and subsequently isolated in almost all known metazoans on this planet.
Hox proteins play an vital role in early patterning along the anterio-posterior axis in all animals.These Hox proteins exhibit some unique properties and different Hox proteins perform some specific functions. In Drosophila , Hox proteins are present in two clusters ,totaling to eight in number.
The sequence divergence of Hox proteins, including within the HD that constitutes the unique DNA binding domain of the Hox transcription factors, allows Hox paralogue proteins to display distinct regulatory functions, promoting axial morphological diversification in all bilaterian animals. (more…) (1073)
Here is another article on Hox -TALE interaction published in PLOS genetics last month. (2006)
Stem cells hold the remarkable capacity of self-renewal and differentiation into more specialized cell types. (115)
The world of RNAs does not seems to stop surprising us, latest being CIRCULAR RNAs controlling gene expression. (843)
Extending further from their work published in Nature journal (321)