If you want to see an ensemble of great minds then “Workshop on HOX and TALE homeoproteins in Development and Disease” in Carmona (Seville) , should be the place for you from 27-30, May 2009 .This work shop is being conducted by Organizers Fernando Casares (CABD, Seville),Miguel Torres (CNIC, Madrid) and Moisés Mallo (IGC, Oeiras) includes some very popular names from the field of Hox . Robb Krumlauf, Richard mann ,Yacine Graba , Adi Salzberg and many other researchers will be presenting their work. ( For the entire list of …

How transcription factors achieve their in vivo specificities is a fundamental question in biology. Regulation of Distalless (dll) gene in insects served as an excellent model to study mechanisms of Hox genes and this is the topic of our classic paper today. Richard mann’s lab published some stunning stuff on role played by segmentation genes in regulation of distalless gene in 2004 Nature issue. This article is a real classic providing some finer details in repression of distalless in abdomen of insects. Ever since the first paper by Vachon et …

New study conducted by Schierwater, B. et al. have shown that the Triploblastic bilaterians and diploblastic animals ( Placozoa,Sponges,Ctenophores and Cnidarians) animals , probably separated very early, at the very beginning of animal evolution and independently evolved their complex body plans, including body axes, nervous system, sensory organs, and other characteristics. In the present study authors analysed morphological and genetic information from 24 metazoan lineages and the resultant phylogeny tree shows a early divergence of simple animals from complex ones ,during the metazoan evolution . One line of the new …

Hox genes are homeodomain containing transcription factors playing a crucial role in patterning the antero-posterior ( AP) axis in bilaterians.The mechanism of patterning by Hox genes is remarkably conserved across the entire bilateria even though huge diversification of body plan exists. The fact that orthologous genes display similar genomic organisation and expression patterns with comparable spatial and temporal characteristics in distantly related species has provided clues for understanding the evolution of the body plan. It was with discovery of homeodomain and later with similarity of Hox clusters in Mice and …

Introduction:
‘Orphans’ was the name given to the these Hox related genes earlier, till Brooke et al in 1998 made it clear that these orphan genes were in fact clustered in Amphioxus, Branchiostoma floridae. This cluster was named ParaHox, which is the paralogue of the Hox cluster. Para Hox genes encode very similar homeodoamain and its very easy to get confused with those of HOX genes in absence of linkage analysis and expression data. In Amphioxus ,these Hox-like genes (Gsx [genomic screened homeobox], Xlox/Ipf1 [Xenopus laevis homeobox 8/insulin promoter factor 1], …

One of the most fascinating thing about life is to understand how we grow from a single celled embryo to a functional human being or for that matter to know about development of all the beautiful forms of life around us. All living organisms arise from a single cell and it was always an interesting puzzle to understand How different tissue forms an organ and how these different organs gets perfectly placed in the animal body?Are these things preplanned ? Is it possible to have eyes coming out from …

Its really heartening to read an article which has neatly designed genetic experiments because its not very often you come across such great genetic work.It surprised me a bit initially not see any biochemical evidence but I personally like this way, may be being a geneticist at heart.Latest issue of development contains an article from the group of Ernesto Sanchez herrero ( an exceptional geneticist) dealing with autoregulation of Hox gene Ultrabithorax (Ubx). Infact autoregulation of Ubx was known since early 90’s but not much was known about mechanism involved …