SHARE THIS ARTICLE         
Home » Featured, HOX
8 March 2013 No Comment

Antagonism Versus Cooperativity with TALE Cofactors at the Base of the Functional Diversification of Hox Protein Function

Here is another article on Hox -TALE interaction published in PLOS genetics last month. I had a minor contribution to this article led by Marisa from James Castelli-Gair lab. Here is the author summary from website.

Hox genes encode transcription factors necessary to achieve the morphological differences between anterior and posterior regions of the body. These genes have been functionally conserved during animal evolution, and similar classes can be recognized in vertebrates and invertebrates. To bind DNA and regulate many of their targets, Hox proteins interact with the MEIS and PBC transcriptional cofactors. However, this is not always the case for the most posteriorly expressed genes belonging to the Abdominal-B class. Here we show a new interaction between the Abd-B protein and these cofactors where, rather than cooperating with Abd-B, the cofactors antagonize its function. Given the conservation of the Hox proteins and their cofactors, this new mode of interaction may be also happening in other species, including vertebrates.

Reference and image Credit:

Citation: Rivas ML, Espinosa-Vázquez JM, Sambrani N, Greig S, Merabet S, et al. (2013) Antagonism Versus Cooperativity with TALE Cofactors at the Base of the Functional Diversification of Hox Protein Function. PLoS Genet 9(2): e1003252. doi:10.1371/journal.pgen.1003252

(3676)

Related Posts:

SHARE THIS ARTICLE          
Share on Facebook

If you liked what you just read, you may want to subscribe to my RSS FEED
Thanks for visiting!

Leave your response!

Add your comment below, or trackback from your own site. You can also subscribe to these comments via RSS.

Be nice. Keep it clean. Stay on topic. No spam.

You can use these tags:
<a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>

This is a Gravatar-enabled weblog. To get your own globally-recognized-avatar, please register at Gravatar.