Post doc position in Alex Gould’s lab
Research in the laboratory mainly utilises the fruit fly Drosophila , a model organism that shares many genes with mammals and has contributed to our understanding of several different aspects of human health and disease. We have recently identified a group of genes expressed in the neural stem cells of Drosophila (called neuroblasts) that are essential for switching off growth of the nervous system and preventing neural tumors in adults. We have also identified /Drosophila/ hepatocyte cells (called oenocytes) that express many enzymes metabolising lipids and are essential for regulating growth and body-fat content. These cells can also be used to model aspects of human hepatic steatosis (fatty liver).
Role of nutrient sensing in Drosophila growth and development.
The successful applicant for this 3 year post doctoral position will use genetics, physiology,molecular biology and biochemistry to study the
roles of nutrient sensing and metabolism during larval growth and fasting in Drosophila (E.Gutierrez et al. 2007. Nature: 445, 275-280).
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